Nonadherence as 4-day Antiretroviral Therapy Interruptions: Do Depression and Race/Ethnicity Matter as Much in the Modern Antiretroviral Therapy Era?

AIDS Behav. 2016 Nov;20(11):2624-2628. doi: 10.1007/s10461-015-1283-8.

Abstract

HIV + White, Latino, and African Americans (N = 1131) completed a survey advertised on social media to re-examine the effect of depressive symptoms (via the Patient Health Questionnaire; PHQ-9) and race/ethnicity on antiretroviral therapy nonadherence (defined as past 3-month, 4-day treatment interruption). An adjusted logistic regression showed a 15 % increase in odds for a treatment interruption per 1-unit increase on the PHQ-9. The effect of depressive symptoms on nonadherence was greater for Latinos (OR = 1.80, p < 0.05), but not for African Americans, compared to Whites. The benefits of modern ART (e.g., simpler, forgiving to minor lapses) may not circumvent the effect of depressive symptomatology.

Keywords: Adherence; Antiretroviral therapy; Depression; Latinos; Race/ethnicity.

Publication types

  • Comparative Study

MeSH terms

  • Adult
  • Anti-HIV Agents / administration & dosage*
  • Black or African American / psychology*
  • Black or African American / statistics & numerical data*
  • Depressive Disorder / ethnology*
  • Depressive Disorder / psychology*
  • Female
  • HIV Infections / drug therapy*
  • HIV Infections / ethnology
  • HIV Infections / psychology
  • Health Surveys
  • Hispanic or Latino / psychology*
  • Hispanic or Latino / statistics & numerical data*
  • Humans
  • Male
  • Medication Adherence / ethnology*
  • Medication Adherence / psychology*
  • Middle Aged
  • Odds Ratio
  • Psychometrics / statistics & numerical data
  • Surveys and Questionnaires
  • United States
  • White People / psychology*
  • White People / statistics & numerical data*

Substances

  • Anti-HIV Agents