Pharmacokinetics of intravenous moxifloxacin in the cerebrospinal fluid of a patient with central nervous system shunt infection

Diagn Microbiol Infect Dis. 2016 Mar;84(3):249-51. doi: 10.1016/j.diagmicrobio.2015.10.001. Epub 2015 Oct 9.

Abstract

We report the first case describing the pharmacokinetics of moxifloxacin in the cerebrospinal fluid after multiple-dose intravenous administration in a patient with central nervous system shunt infection. The ratio of the area under the concentration-time curve over 24h (AUC) in cerebrospinal fluid to the AUC in serum was 0.7 in this patient.

Keywords: Cerebrospinal fluid; Intravenous; Moxifloxacin; Pharmacokinetics.

Publication types

  • Case Reports

MeSH terms

  • Administration, Intravenous
  • Anti-Bacterial Agents / administration & dosage
  • Anti-Bacterial Agents / pharmacokinetics*
  • Central Nervous System Bacterial Infections / diagnosis
  • Central Nervous System Bacterial Infections / drug therapy*
  • Fluoroquinolones / administration & dosage
  • Fluoroquinolones / pharmacokinetics*
  • Humans
  • Male
  • Middle Aged
  • Moxifloxacin
  • Treatment Outcome

Substances

  • Anti-Bacterial Agents
  • Fluoroquinolones
  • Moxifloxacin