Acute myeloid leukemia of a primary hepatic carcinoma patient after liver transplantation: a case report and literature review

Int J Clin Exp Pathol. 2015 Oct 1;8(10):13655-60. eCollection 2015.

Abstract

Living donor liver transplantation (LDLT) is an important means to treat end-stage liver disease. Although effective immunosuppressant medication greatly assists the survival of patients, it is likely to promote infections and cancer. Acute leukemia (AL) is a rare complication after LDLT and up to now only 1 case of post-transplantation AL has occurred in our liver transplantation center after more than 1,600 LDLT interventions since 1993. In the present report, we describe a rare case of subsequent acute myeloid leukemia (AML), 27 months after LDLT and review the literature of this infrequent complication.

Keywords: Acute myeloid leukemia; alpha-fetoprotein; hepatic carcinoma; liver transplantation; metastases.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Carcinoma, Hepatocellular / pathology
  • Carcinoma, Hepatocellular / surgery*
  • Fatal Outcome
  • Humans
  • Immunosuppressive Agents / adverse effects*
  • Immunosuppressive Agents / therapeutic use
  • Leukemia, Myeloid, Acute / etiology*
  • Leukemia, Myeloid, Acute / pathology
  • Liver / pathology
  • Liver Neoplasms / pathology
  • Liver Neoplasms / surgery*
  • Liver Transplantation / adverse effects*
  • Male
  • Middle Aged
  • alpha-Fetoproteins / analysis

Substances

  • Immunosuppressive Agents
  • alpha-Fetoproteins