The Role of Prostaglandin E(2) in Tumor-Associated Immunosuppression

Dingzhi Wang; Raymond N DuBois

doi:10.1016/j.molmed.2015.11.003

The Role of Prostaglandin E(2) in Tumor-Associated Immunosuppression

Trends Mol Med. 2016 Jan;22(1):1-3. doi: 10.1016/j.molmed.2015.11.003. Epub 2015 Dec 17.

Authors

Dingzhi Wang¹, Raymond N DuBois²

Affiliations

¹ Laboratory for Inflammation and Cancer, the Biodesign Institute at Arizona State University, Tempe, AZ 85287, USA.
² Laboratory for Inflammation and Cancer, the Biodesign Institute at Arizona State University, Tempe, AZ 85287, USA; Department of Chemistry and Biochemistry, Arizona State University, Tempe, AZ 85287, USA; Department of Research and Division of Gastroenterology, Mayo Clinic, Scottsdale, AZ 85259, USA. Electronic address: duboisrn@asu.edu.

Abstract

Tumor-associated inflammation can create an immunosuppressive microenvironment allowing tumor cells to escape immunosurveillance. Inhibiting immunosuppression remains one of the major challenges in cancer immunotherapy via checkpoint inhibitors. Recent preclinical data from the Reis e Sousa group may provide a strong rationale for developing new therapeutics to subvert tumor-induced immunosuppression via prostaglandin inhibition.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Comment

MeSH terms

Animals
Humans
Neoplasms / immunology*
Prostaglandin-Endoperoxide Synthases / metabolism*
Tumor Escape*

Substances

Prostaglandin-Endoperoxide Synthases

Abstract

Publication types

MeSH terms

Substances

Grants and funding