Genetic predisposition to acute lymphoblastic leukemia: Overview on behalf of the I-BFM ALL Host Genetic Variation Working Group

Christian Peter Kratz; Martin Stanulla; Hélène Cavé

doi:10.1016/j.ejmg.2015.10.003

Genetic predisposition to acute lymphoblastic leukemia: Overview on behalf of the I-BFM ALL Host Genetic Variation Working Group

Eur J Med Genet. 2016 Mar;59(3):111-5. doi: 10.1016/j.ejmg.2015.10.003. Epub 2015 Dec 15.

Authors

Christian Peter Kratz¹, Martin Stanulla², Hélène Cavé³

Affiliations

¹ Pediatric Hematology and Oncology, Hannover Medical School, Hannover, Germany. Electronic address: kratz.christian@mh-hannover.de.
² Pediatric Hematology and Oncology, Hannover Medical School, Hannover, Germany.
³ Assistance Publique des Hôpitaux de Paris (AP-HP), Hôpital Robert Debré, Département de Génétique, Paris, France; INSERM UMR 1131, Institut Universitaire d'Hématologie, Université Paris Diderot, Paris-Sorbonne-Cité, Paris, France.

PMID: 26699264
DOI: 10.1016/j.ejmg.2015.10.003

Abstract

Environmental causes of childhood acute lymphoblastic leukemia (ALL) remain largely undiscovered. In contrast, multiple germline ALL risk variants have been identified in the recent years. Apart from the low-risk common ALL risk alleles identified through genome wide association studies, rare germline mutations that cause cancer prone syndromes have been found to be associated with an increased risk of developing ALL. Here, we review the germline genetic changes known to be associated with ALL.

Keywords: Acute lymphoblastic leukemia; Cancer predisposition; Germline mutation; Risk variants.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Age Factors
Alleles
Genetic Association Studies
Genetic Predisposition to Disease*
Genetic Variation*
Germ-Line Mutation
Humans
Incidence
Penetrance
Precursor Cell Lymphoblastic Leukemia-Lymphoma / genetics*
Risk
Syndrome