A novel peptide adropin in cardiovascular diseases

Clin Chim Acta. 2016 Jan 30:453:107-13. doi: 10.1016/j.cca.2015.12.010. Epub 2015 Dec 10.

Abstract

Cardiovascular diseases, such as atherosclerosis and hypertension, are the major cause of mortality and morbidity in the world. Adropin was first discovered in 2008 by Kumar and his coworkers. Adropin, encoded by the Energy Homeostasis Associated gene, is expressed in many tissues and organs, such as pancreatic tissue, liver, brain, kidney, endocardium, myocardium, and epicardium. In this review, we have summarized recent data suggesting the roles of adropin in several major cardiovascular diseases. Increasing evidence suggests that adropin is a potential regulator of cardiovascular functions and plays a protective role in the pathogenesis and development of cardiovascular diseases. However, further studies are needed to elucidate the specific mechanisms underlying the association between adropin and cardiovascular diseases.

Keywords: Adropin; Atherosclerosis; Coronary artery disease; Heart failure; Hypertension.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Blood Proteins / chemistry
  • Blood Proteins / genetics
  • Blood Proteins / metabolism*
  • Cardiovascular Diseases / genetics
  • Cardiovascular Diseases / metabolism*
  • Gene Expression Regulation
  • Humans
  • Intercellular Signaling Peptides and Proteins
  • Peptides / chemistry
  • Peptides / genetics
  • Peptides / metabolism*

Substances

  • Blood Proteins
  • Enho protein, human
  • Intercellular Signaling Peptides and Proteins
  • Peptides