Fluorine-18 patents (2009-2015). Part 1: novel radiotracers

Allen F Brooks; Lindsey R Drake; Megan N Stewart; Brian P Cary; Isaac M Jackson; Dale Mallette; Andrew V Mossine; Peter J H Scott

doi:10.4155/ppa.15.36

Fluorine-18 patents (2009-2015). Part 1: novel radiotracers

Pharm Pat Anal. 2016;5(1):17-47. doi: 10.4155/ppa.15.36. Epub 2015 Dec 16.

Authors

Allen F Brooks¹, Lindsey R Drake², Megan N Stewart², Brian P Cary¹, Isaac M Jackson¹, Dale Mallette¹, Andrew V Mossine¹, Peter J H Scott^{1

2}

Affiliations

¹ Department of Radiology, University of Michigan Medical School, 1301 Catherine St., Ann Arbor, MI 48109, USA.
² Department of Medicinal Chemistry, University of Michigan, 428 Church St., Ann Arbor, MI 48109, USA.

Abstract

The most commonly utilized PET radionuclide is fluorine-18 ((18)F) because of its convenient half-life and excellent imaging properties. In this review, we present the first analysis of patents issued for radiotracers labeled with fluorine-18 (between 2009 and 2015), and provide perspective on current trends and future directions in PET radiotracer development.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Review

MeSH terms

Animals
Fluorine Radioisotopes*
Heart Diseases / diagnostic imaging
Humans
Neoplasms / diagnostic imaging
Nervous System Diseases / diagnostic imaging
Neuroimaging
Patents as Topic
Radionuclide Imaging
Radiopharmaceuticals*

Substances

Fluorine Radioisotopes
Radiopharmaceuticals

Abstract

Publication types

MeSH terms

Substances

Grants and funding