Abstract
(±)-Asenapine, sold in the market as Saphris/Sycrest for the treatment of bipolar disorders, is synthesized in an optically pure form involving an Ireland-Claisen rearrangement as the key step. This approach allows access to all diastereomers.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Antipsychotic Agents / chemical synthesis*
-
Crystallography, X-Ray
-
Dibenzocycloheptenes
-
Heterocyclic Compounds, 4 or More Rings / chemical synthesis*
-
Heterocyclic Compounds, 4 or More Rings / chemistry
-
Humans
-
Models, Molecular
-
Molecular Structure
-
Schizophrenia / drug therapy*
-
Stereoisomerism
Substances
-
Antipsychotic Agents
-
Dibenzocycloheptenes
-
Heterocyclic Compounds, 4 or More Rings
-
asenapine