Role of redoximiRs in fibrogenesis

Redox Biol. 2016 Apr:7:58-67. doi: 10.1016/j.redox.2015.11.006. Epub 2015 Nov 19.

Abstract

Fibrosis can be defined as an excessive accumulation of extracellular matrix (ECM) components, ultimately leading to stiffness, scarring and devitalized tissue. MicroRNAs (miRNAs) are short, 19-25 nucleotides (nt), non-coding RNAs involved in the post-transcriptional regulation of gene expression. Recently, miRNAs have also emerged as powerful regulators of fibrotic processes and have been termed "fibromiRs". Oxidative stress represents a self-perpetuating mechanism in fibrogenesis. MiRNAs can also influence the expression of genes responsible for the generation of reactive oxygen species (ROS) and antioxidant defence and are termed "redoximiRs". Here, we review the current knowledge of mechanisms by which "redoximiRs" regulate fibrogenesis. This new set of miRNAs may be called "redoxifibromiRs".

Keywords: Fibrosis; MicroRNAs; Oxidative stress.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Fibrosis
  • Gene Expression Regulation
  • Heart Diseases / genetics*
  • Humans
  • Kidney Diseases / genetics*
  • Liver Cirrhosis / genetics*
  • MicroRNAs / genetics*
  • Oxidative Stress
  • Pulmonary Fibrosis / genetics*
  • Reactive Oxygen Species / metabolism
  • Signal Transduction
  • Skin Diseases / genetics*

Substances

  • MicroRNAs
  • Reactive Oxygen Species