Maternal Serum Resistin Is Reduced in First Trimester Preeclampsia Pregnancies and Is a Marker of Clinical Severity

Michael Christiansen; Paula L Hedley; Sophie Placing; Karen R Wøjdemann; Anting L Carlsen; Jennifer M Jørgensen; Anne-Cathrine Gjerris; Anne-Cathrine Shalmi; Line Rode; Karin Sundberg; Ann Tabor

doi:10.3109/10641955.2014.913615

Maternal Serum Resistin Is Reduced in First Trimester Preeclampsia Pregnancies and Is a Marker of Clinical Severity

Hypertens Pregnancy. 2015 Nov;34(4):422-433. doi: 10.3109/10641955.2014.913615. Epub 2015 Dec 4.

Authors

Affiliations

¹ a Department of Clinical Biochemistry , Statens Serum Institut , Copenhagen , Denmark .
² b Department of Biomedical Sciences , Stellenbosch University , Cape Town , South Africa .
³ c Department of Fetal Medicine , Rigshospitalet , Copenhagen , Denmark .
⁴ d Department of Obstetrics and Gynecology , Roskilde Hospital , Roskilde , Denmark .
⁵ e Department of Obstetrics and Gynecology , Hillerød Hospital , Hillerød , Denmark.

PMID: 26636480
DOI: 10.3109/10641955.2014.913615

Abstract

Objective: To examine whether resistin levels in first trimester maternal serum are associated with insulin resistance or preeclampsia (PE).

Methods: A case-control study of maternal serum resistin concentration conducted using 285 normal pregnancies and 123 PE pregnancies matched for gestational age, parity and maternal age. Samples were taken in gestational weeks 10⁺⁰-13⁺⁶.

Results: There was a negative correlation between resistin and clinical severity of PE, but no correlation with IS, TNF-α, body mass index, birth weight and pregnancy length.

Conclusions: Resistin is reduced in first trimester of PE pregnancies, particularly in severe PE. Inflammation and IS cannot explain this phenomenon.

Keywords: placenta; pre-eclampsia; prenatal screening.