Non-Toxigenic Penicillin and Cephalosporin-Resistant Corynebacterium diphtheriae Endocarditis in a Child: A Case Report and Review of the Literature

Marielle J Fricchione; Heidi J Deyro; Christine Y Jensen; Joan F Hoffman; Kamalijit Singh; Latania K Logan

doi:10.1093/jpids/pit022

Non-Toxigenic Penicillin and Cephalosporin-Resistant Corynebacterium diphtheriae Endocarditis in a Child: A Case Report and Review of the Literature

J Pediatric Infect Dis Soc. 2014 Sep;3(3):251-4. doi: 10.1093/jpids/pit022. Epub 2013 Apr 12.

Authors

Marielle J Fricchione¹, Heidi J Deyro¹, Christine Y Jensen¹, Joan F Hoffman², Kamalijit Singh³, Latania K Logan⁴

Affiliations

¹ Department of Pediatrics.
² Department of Pediatrics The Center for Congenital and Structural Heart Disease.
³ Division of Infectious Diseases, Department of Medicine Department of Microbiology.
⁴ Department of Pediatrics Section of Pediatric Infectious Diseases, Rush University Medical Center, Rush Medical College, Chicago, Illinois.

PMID: 26625388
DOI: 10.1093/jpids/pit022

Abstract

Reports of invasive disease caused by non-toxigenic Corynebacterium diphtheriae are increasing; however, medical management has not been extensively studied. We describe what we believe is the first documented case of penicillin and cephalosporin-resistant C diphtheriae endocarditis in a child successfully treated with vancomycin, meropenem, and valvular replacement surgery.

Keywords: Corynebacterium diphtheriae; antibiotic resistance; endocarditis.