Neuropsychiatric Features in Primary Mitochondrial Disease

Samantha E Marin; Russell P Saneto

doi:10.1016/j.ncl.2015.08.011

Neuropsychiatric Features in Primary Mitochondrial Disease

Neurol Clin. 2016 Feb;34(1):247-94. doi: 10.1016/j.ncl.2015.08.011.

Authors

Samantha E Marin¹, Russell P Saneto²

Affiliations

¹ Department of Neurosciences, University of California, San Diego (UCSD), 9500 Gilman Drive #0935, La Jolla, CA 92093-0935, USA.
² Department of Neurology, Seattle Children's Hospital, University of Washington, 4800 Sand Point Way Northeast, Seattle, WA 98105, USA; Department of Pediatrics, Seattle Children's Hospital, University of Washington, 4800 Sand Point Way Northeast, Seattle, WA 98105, USA. Electronic address: russ.saneto@seattlechildrens.org.

PMID: 26614002
DOI: 10.1016/j.ncl.2015.08.011

Abstract

Mitochondrial diseases are a clinically heterogeneous group of disorders that ultimately result from dysfunction of the mitochondrial respiratory chain. There is some evidence to suggest that mitochondrial dysfunction plays a role in neuropsychiatric illness; however, the data are inconclusive. This article summarizes the available literature published in the area of neuropsychiatric manifestations in both children and adults with primary mitochondrial disease, with a focus on autism spectrum disorder in children and mood disorders and schizophrenia in adults.

Keywords: Anxiety; Autism; Behavioral; Bipolar disorder; Depression; Mitochondrial; Neuropsychiatric; Schizophrenia.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review

MeSH terms

Adult
Autism Spectrum Disorder / etiology*
Autism Spectrum Disorder / psychology
Child
Humans
Mental Disorders / etiology*
Mental Disorders / psychology
Mitochondrial Diseases / complications*
Mitochondrial Diseases / psychology

Grants and funding

2U54NS078059-04/NS/NINDS NIH HHS/United States