Concomitant gain of 1q21 and MYC translocation define a poor prognostic subgroup of hyperdiploid multiple myeloma

Haematologica. 2016 Mar;101(3):e116-9. doi: 10.3324/haematol.2015.136929. Epub 2015 Nov 26.
No abstract available

Keywords: MYC rearrangements; cytogenetics and molecular genetics; multiple myeloma; outcome.

Publication types

  • Clinical Trial
  • Letter
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antineoplastic Agents / therapeutic use
  • Chromosomes, Human, Pair 1 / chemistry*
  • Gene Deletion
  • Gene Expression
  • Genetic Loci
  • Humans
  • Multiple Myeloma / diagnosis
  • Multiple Myeloma / drug therapy
  • Multiple Myeloma / genetics*
  • Multiple Myeloma / mortality
  • Mutagenesis, Insertional
  • Neoplasm Staging
  • Plasma Cells / drug effects
  • Plasma Cells / metabolism*
  • Plasma Cells / pathology
  • Ploidies
  • Prognosis
  • Proto-Oncogene Proteins c-myc / genetics*
  • Proto-Oncogene Proteins c-myc / metabolism
  • Survival Analysis
  • Translocation, Genetic*

Substances

  • Antineoplastic Agents
  • MYC protein, human
  • Proto-Oncogene Proteins c-myc

Associated data

  • EudraCT/2004-000944-26