Utility of Combining PET and MR Imaging of Carotid Plaque

Alex T Vesey; Marc R Dweck; Zahi A Fayad

doi:10.1016/j.nic.2015.09.005

Utility of Combining PET and MR Imaging of Carotid Plaque

Neuroimaging Clin N Am. 2016 Feb;26(1):55-68. doi: 10.1016/j.nic.2015.09.005.

Authors

Alex T Vesey¹, Marc R Dweck², Zahi A Fayad³

Affiliations

¹ British Heart Foundation Centre for Cardiovascular Science, College of Medicine and Veterinary Medicine, University of Edinburgh, Room Suite 305, The Chancellor's Building, 49 Little France Crescent, Edinburgh EH16 4SB, UK.
² British Heart Foundation Centre for Cardiovascular Science, College of Medicine and Veterinary Medicine, University of Edinburgh, Room Suite 305, The Chancellor's Building, 49 Little France Crescent, Edinburgh EH16 4SB, UK; Imaging Science Laboratories, Department of Radiology, Translational and Molecular Imaging Institute, Mount Sinai School of Medicine, 1 Gustave L. Levy Place, New York, NY 10029, USA; Imaging Science Laboratories, Department of Medicine, Translational and Molecular Imaging Institute, Mount Sinai School of Medicine, 1 Gustave L. Levy Place, New York, NY 10029, USA.
³ Imaging Science Laboratories, Department of Radiology, Translational and Molecular Imaging Institute, Mount Sinai School of Medicine, 1 Gustave L. Levy Place, New York, NY 10029, USA; Imaging Science Laboratories, Department of Medicine, Translational and Molecular Imaging Institute, Mount Sinai School of Medicine, 1 Gustave L. Levy Place, New York, NY 10029, USA. Electronic address: zahi.fayad@mssm.edu.

PMID: 26610660
DOI: 10.1016/j.nic.2015.09.005

Abstract

By harnessing the versatility and soft tissue imaging capabilities of MR imaging alongside the unmatched sensitivity and biomolecular flexibility of PET, the potential to provide detailed multiparametric plaque characterization in the carotid arteries is clear. The ability to acquire simultaneous, and dynamic multimodal data is perhaps PET/MR's greatest strength that will be of major interest to researchers investigating carotid and coronary atherosclerosis alike. This review summarizes the current status of dedicated hybrid PET/MR imaging; to crystallize the rationale for and advantages of this technique with respect to carotid atherosclerosis; and to discuss current limitations, challenges, and future directions.

Keywords: Carotid plaque imaging; MR imaging; PET.

Publication types

Review

MeSH terms

Algorithms*
Carotid Stenosis / diagnosis*
Humans
Image Interpretation, Computer-Assisted / methods*
Magnetic Resonance Angiography / methods*
Multimodal Imaging / methods*
Positron-Emission Tomography / methods*
Reproducibility of Results
Sensitivity and Specificity

Abstract

Publication types

MeSH terms

Grants and funding