Dual-energy computed tomography for detection of coronary artery disease

Expert Rev Cardiovasc Ther. 2015 Dec;13(12):1345-56. doi: 10.1586/14779072.2015.1102055. Epub 2015 Nov 7.

Abstract

Recent technological advances in computed tomography (CT) technology have fulfilled the prerequisites for the cardiac application of dual-energy CT (DECT) imaging. By exploiting the unique characteristics of materials when exposed to two different x-ray energies, DECT holds great promise for the diagnosis and management of coronary artery disease. It allows for the assessment of myocardial perfusion to discern the hemodynamic significance of coronary disease and possesses high accuracy for the detection and characterization of coronary plaques, while facilitating reductions in radiation dose. As such, DECT enabled cardiac CT to advance beyond the mere detection of coronary stenosis expanding its role in the evaluation and management of coronary atherosclerosis.

Keywords: CT perfusion; cardiac dual-energy CT; diagnostic accuracy; plaque characterization; radiation dose aspects; specifications of DECT.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Coronary Artery Disease* / complications
  • Coronary Artery Disease* / diagnosis
  • Humans
  • Myocardial Ischemia* / diagnosis
  • Myocardial Ischemia* / etiology
  • Myocardial Perfusion Imaging / methods
  • Radiography, Dual-Energy Scanned Projection / methods
  • Reproducibility of Results
  • Tomography, X-Ray Computed / methods*