Thoracoscopic Resection of Multiple Müllerian Cysts

Matthew D Skancke; Tanya D Auzenne; Sana O Tabbara; Keith D Mortman

doi:10.1016/j.athoracsur.2015.01.076

Thoracoscopic Resection of Multiple Müllerian Cysts

Ann Thorac Surg. 2015 Nov;100(5):1898-900. doi: 10.1016/j.athoracsur.2015.01.076.

Authors

Matthew D Skancke¹, Tanya D Auzenne², Sana O Tabbara², Keith D Mortman³

Affiliations

¹ Department of Surgery, The George Washington University Hospital, Washington, DC.
² Department of Pathology, The George Washington University Hospital, Washington, DC.
³ Department of Surgery, The George Washington University Hospital, Washington, DC. Electronic address: kmortman@mfa.gwu.edu.

PMID: 26522538
DOI: 10.1016/j.athoracsur.2015.01.076

Abstract

Müllerian cysts in the mediastinum were first described by Hattori in 2005 [1]. We report the first known case of multiple müllerian cysts in the thorax in a 35-year-old woman with cough and an abnormal chest roentgenogram. Multiple bilateral cysts were resected thoracoscopically. Histologic examination showed benign ciliated tubal epithelium that stained positive with immunohistochemical stains for estrogen receptor (ER), cancer antigen 125 (CA-125), Wilms' tumor protein 1 (WT-1), and paired box gene 8 (PAX8), confirming müllerian origin. We also review the embryogenesis and pathologic characteristics of müllerian cysts and the rare occurrence of their migration to the thorax.

Publication types

Case Reports

MeSH terms

Adult
CA-125 Antigen / metabolism
Epithelium / pathology
Female
Humans
Immunohistochemistry
Mediastinal Cyst / metabolism
Mediastinal Cyst / pathology
Mediastinal Cyst / surgery*
Mullerian Ducts* / pathology
PAX8 Transcription Factor
Paired Box Transcription Factors / metabolism
Receptors, Estrogen / metabolism
Thoracoscopy*
WT1 Proteins / metabolism

Substances

CA-125 Antigen
PAX8 Transcription Factor
PAX8 protein, human
Paired Box Transcription Factors
Receptors, Estrogen
WT1 Proteins
WT1 protein, human