Delayed diagnosis leading to accelerated-phase chronic eosinophilic leukemia due to a cytogenetically cryptic, imatinib-responsive TNIP1-PDFGRB fusion gene

D M Ross; H K Altamura; C N Hahn; M Nicola; A L Yeoman; M R Holloway; J Geoghegan; J Feng; A W Schreiber; S Branford; S Moore; H S Scott

doi:10.1038/leu.2015.301

Delayed diagnosis leading to accelerated-phase chronic eosinophilic leukemia due to a cytogenetically cryptic, imatinib-responsive TNIP1-PDFGRB fusion gene

Leukemia. 2016 Jun;30(6):1402-5. doi: 10.1038/leu.2015.301. Epub 2015 Oct 27.

Authors

D M Ross^{1

2

3}, H K Altamura⁴, C N Hahn^{3

4

5}, M Nicola⁴, A L Yeoman⁴, M R Holloway⁴, J Geoghegan⁶, J Feng^{5

6

7}, A W Schreiber^{5

6

7}, S Branford^{4

5

8}, S Moore⁴, H S Scott^{3

4

5

6

7

8}

Affiliations

¹ Haematology Directorate, SA Pathology, Adelaide, South Australia, Australia.
² Flinders University and Medical Centre, Adelaide, South Australia, Australia.
³ School of Medicine, University of Adelaide, Adelaide, South Australia, Australia.
⁴ Genetics and Molecular Pathology Directorate, SA Pathology, Adelaide, South Australia, Australia.
⁵ Centre for Cancer Biology, SA Pathology, Adelaide, South Australia, Australia.
⁶ Australian Cancer Research Foundation Genomics Facility, SA Pathology, Adelaide, South Australia, Australia.
⁷ School of Biological Sciences, University of Adelaide, Adelaide, South Australia, Australia.
⁸ School of Pharmacy and Medical Science, University of South Australia, Adelaide, South Australia, Australia.

PMID: 26503642
DOI: 10.1038/leu.2015.301

No abstract available

Publication types

Case Reports
Letter

MeSH terms

Aged
Antineoplastic Agents, Immunological / pharmacology*
Chronic Disease
DNA-Binding Proteins / genetics*
Delayed Diagnosis*
Gene Fusion*
Humans
Hypereosinophilic Syndrome / diagnosis*
Hypereosinophilic Syndrome / genetics
Imatinib Mesylate / pharmacology*
In Situ Hybridization, Fluorescence
Male
Polymorphism, Single Nucleotide
Proto-Oncogene Proteins c-sis / genetics*

Substances

Antineoplastic Agents, Immunological
DNA-Binding Proteins
Proto-Oncogene Proteins c-sis
TNIP1 protein, human
Imatinib Mesylate