How does HTLV-1 cause adult T-cell leukaemia/lymphoma (ATL)?

Charles R M Bangham; Lee Ratner

doi:10.1016/j.coviro.2015.09.004

How does HTLV-1 cause adult T-cell leukaemia/lymphoma (ATL)?

Curr Opin Virol. 2015 Oct:14:93-100. doi: 10.1016/j.coviro.2015.09.004. Epub 2015 Sep 27.

Authors

Charles R M Bangham¹, Lee Ratner²

Affiliations

¹ Section of Virology, Department of Medicine, Imperial College, London W2 1PG, UK. Electronic address: c.bangham@imperial.ac.uk.
² Medical Oncology Section, Hematology-Oncology Faculty, Washington University School of Medicine, St Louis, WA, USA.

Abstract

A typical person infected with the retrovirus human T-lymphotropic virus type 1 (HTLV-1) carries tens of thousands of clones of HTLV-1-infected T lymphocytes, each clone distinguished by a unique integration site of the provirus in the host genome. However, only 5% of infected people develop the malignant disease adult T cell leukaemia/lymphoma, usually more than 50 years after becoming infected. We review the host and viral factors that cause this aggressive disease.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review

MeSH terms

Host-Pathogen Interactions*
Human T-lymphotropic virus 1 / physiology*
Humans
Leukemia-Lymphoma, Adult T-Cell / pathology*
Leukemia-Lymphoma, Adult T-Cell / virology*

Abstract

Publication types

MeSH terms

Grants and funding