Pannorin B, a new naphthopyrone from an endophytic fungal isolate of Penicillium sp

Magn Reson Chem. 2016 Feb;54(2):164-7. doi: 10.1002/mrc.4324. Epub 2015 Sep 14.

Abstract

Pannorin B (1), a new naphthopyrone derivative, was obtained from an endophytic fungal culture of Penicillium sp. (G324), which was isolated from the leaves of milk thistle (Silybum marianum). Four known compounds, including O-methyldihydrogladiolic acid (2), 10,20-dehydro[12,13-dehydroprolyl-2-(1,1-dimethylallyltryptophyl)diketopiperazine] (3), 12,13-dehydroprolyl-2-(1,1-dimethylallyltryptophyl)diketopiperazine (4), and deoxybrevianamide E (5) were also encountered. The structures of 1–5 were determined via analysis of a suite of NMR and MS data.

Keywords: 13C NMR; 1H NMR; NMR; Penicillium sp; Silybum marianum; fungal endophyte; milk thistle; secondary metabolite.

Publication types

  • Letter
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Diketopiperazines / chemistry
  • Diketopiperazines / isolation & purification
  • Indoles / chemistry
  • Indoles / isolation & purification
  • Lactones / chemistry
  • Lactones / isolation & purification
  • Naphthalenes / chemistry*
  • Naphthalenes / isolation & purification*
  • Naphthols / chemistry*
  • Naphthols / isolation & purification
  • Penicillium
  • Proton Magnetic Resonance Spectroscopy
  • Pyrones / chemistry*
  • Pyrones / isolation & purification
  • Silybum marianum / chemistry*

Substances

  • Diketopiperazines
  • Indoles
  • Lactones
  • Naphthalenes
  • Naphthols
  • Pyrones
  • pannorin B