Persistence of Aβ seeds in APP null mouse brain

Lan Ye; Sarah K Fritschi; Juliane Schelle; Ulrike Obermüller; Karoline Degenhardt; Stephan A Kaeser; Yvonne S Eisele; Lary C Walker; Frank Baumann; Matthias Staufenbiel; Mathias Jucker

doi:10.1038/nn.4117

Persistence of Aβ seeds in APP null mouse brain

Nat Neurosci. 2015 Nov;18(11):1559-61. doi: 10.1038/nn.4117. Epub 2015 Sep 9.

Authors

Lan Ye^{1

2

3}, Sarah K Fritschi^{1

2}, Juliane Schelle^{1

2

3}, Ulrike Obermüller^{1

2}, Karoline Degenhardt^{1

2

3}, Stephan A Kaeser^{1

2}, Yvonne S Eisele^{1

2}, Lary C Walker⁴, Frank Baumann^{1

2}, Matthias Staufenbiel^{1

2}, Mathias Jucker^{1

2}

Affiliations

¹ Department of Cellular Neurology, Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany.
² German Center for Neurodegenerative Diseases (DZNE), Tübingen, Tübingen, Germany.
³ Graduate School of Cellular and Molecular Neuroscience, University of Tübingen, Tübingen, Germany.
⁴ Yerkes National Primate Research Center and Department of Neurology, Emory University, Atlanta, Georgia, USA.

PMID: 26352792
DOI: 10.1038/nn.4117

Abstract

Cerebral β-amyloidosis is induced by inoculation of Aβ seeds into APP transgenic mice, but not into App(-/-) (APP null) mice. We found that brain extracts from APP null mice that had been inoculated with Aβ seeds up to 6 months previously still induced β-amyloidosis in APP transgenic hosts following secondary transmission. Thus, Aβ seeds can persist in the brain for months, and they regain propagative and pathogenic activity in the presence of host Aβ.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Alzheimer Disease / metabolism*
Alzheimer Disease / pathology
Amyloid beta-Protein Precursor / administration & dosage
Amyloid beta-Protein Precursor / deficiency
Amyloid beta-Protein Precursor / metabolism
Amyloid beta-Protein Precursor / pharmacology*
Amyloidosis / pathology
Animals
Brain / drug effects*
Brain / metabolism*
Brain / pathology
Disease Models, Animal
Mice, Inbred C57BL
Mice, Knockout
Mice, Transgenic
Plaque, Amyloid / metabolism*
Plaque, Amyloid / pathology

Substances

Amyloid beta-Protein Precursor