Transformation of IGHV4-34+ hairy cell leukaemia-variant with U2AF1 mutation into a clonally-related high grade B-cell lymphoma responding to immunochemotherapy

Br J Haematol. 2016 May;173(3):491-5. doi: 10.1111/bjh.13627. Epub 2015 Aug 25.
No abstract available

Keywords: IGHV4-34 rearrangement; U2AF1 mutation; cyclin D1; hairy-cell leukaemia variant; lymphoma transformation.

Publication types

  • Case Reports
  • Letter
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Cell Transformation, Neoplastic / pathology*
  • Clone Cells
  • Genes, Immunoglobulin Heavy Chain
  • Genetic Variation
  • Humans
  • Immunotherapy
  • Leukemia, Hairy Cell / genetics*
  • Leukemia, Hairy Cell / pathology
  • Lymphoma, B-Cell / drug therapy*
  • Lymphoma, B-Cell / genetics
  • Male
  • Mutation
  • Remission Induction
  • Splicing Factor U2AF / genetics*
  • Treatment Outcome

Substances

  • Splicing Factor U2AF
  • U2AF1 protein, human