The development of NMR technique is surprisingly progressive also at present. In this article, firstly we want to report our clinical experiments about mainly congenital and development anomalies, vascular disorders, dysmyelinating or demyelinating disorders, and neurodegenerative disorders. Secondly we report about the new techniques of MR imaging and MR spectroscopy those are applicable in clinical studies at present and in the near future. Fast scan imaging technique using gradient echo acquisition enables us to perform CSF cine-mode study, MR angiography, and three-dimensional imaging. Detectability of intracranial calcification is higher in the fast scan images than in the conventional spin-echo images. MR imaging and spectroscopy using other than proton are not performed screening at present. However, in vivo MR imaging of sodium, fluorine, and phosphorus can be used, and their clinical utilities are now evaluated. In vivo MR spectroscopy of proton is also used in some institutes. Its clinical utility is already reported and this application in clinical studies is strongly expected.