Early detection with the β-LACTA™ test of extended-spectrum β-lactamase-producing Enterobacteriaceae in blood cultures

V Walewski; I Podglajen; P Lefeuvre; F Dutasta; A Neuschwander; L Tilouche; E Carbonnelle; A Ferroni

doi:10.1016/j.diagmicrobio.2015.07.005

Early detection with the β-LACTA™ test of extended-spectrum β-lactamase-producing Enterobacteriaceae in blood cultures

Diagn Microbiol Infect Dis. 2015 Nov;83(3):216-8. doi: 10.1016/j.diagmicrobio.2015.07.005. Epub 2015 Jul 15.

Authors

V Walewski¹, I Podglajen², P Lefeuvre³, F Dutasta⁴, A Neuschwander⁴, L Tilouche⁴, E Carbonnelle², A Ferroni⁵

Affiliations

¹ Microbiology, AP-HP, Hôpital Européen Georges Pompidou, Paris, France. Electronic address: violaine.walewski@aphp.fr.
² Microbiology, AP-HP, Hôpital Européen Georges Pompidou, Paris, France; Université Paris Descartes, Paris, France.
³ Microbiology, AP-HP, Hôpital Necker-Enfants Malades, Paris, France.
⁴ Microbiology, AP-HP, Hôpital Européen Georges Pompidou, Paris, France.
⁵ Université Paris Descartes, Paris, France; Microbiology, AP-HP, Hôpital Necker-Enfants Malades, Paris, France.

PMID: 26256418
DOI: 10.1016/j.diagmicrobio.2015.07.005

Abstract

Effective antibiotic therapy is crucial for the outcome of septic patients and requires early diagnosis of β-lactam resistance in cases of Gram-negative bacteremia. Here, we report high sensitivity of the β-LACTA™ test in rapid detection of extended-spectrum β-lactamase-producing Enterobacteriaceae in blood cultures positive for Gram-negative bacilli.

Keywords: Beta-lactamin; ESBL; Enterobacteriaceae; antibiotic resistance; rapid diagnostic test.

Publication types

Evaluation Study

MeSH terms

Bacteremia / diagnosis*
Blood / microbiology*
Enterobacteriaceae / enzymology*
Enterobacteriaceae / isolation & purification*
Enterobacteriaceae Infections / diagnosis*
Humans
Sensitivity and Specificity
beta-Lactamases / metabolism*

Substances

beta-Lactamases