Induced pluripotent stem cells (iPSCs) derived from frontotemporal dementia patient's peripheral blood mononuclear cells

Stem Cell Res. 2015 Sep;15(2):325-7. doi: 10.1016/j.scr.2015.07.004. Epub 2015 Jul 21.

Abstract

Peripheral blood mononuclear cells (PBMC) were donated by a patient with clinically diagnosed frontotemporal dementia (FTD). Induced pluripotent stem cells (iPSCs) were developed using integration-free CytoTune-iPS Sendai Reprogramming factors which include Sendai virus particles of the four Yamanaka factors Oct, Sox2, Klf4, and c-Myc.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Cell Differentiation
  • Cellular Reprogramming*
  • Frontotemporal Dementia / metabolism
  • Frontotemporal Dementia / pathology*
  • Genetic Vectors / genetics
  • Genetic Vectors / metabolism
  • Humans
  • Induced Pluripotent Stem Cells / cytology*
  • Induced Pluripotent Stem Cells / metabolism*
  • Karyotyping
  • Kruppel-Like Factor 4
  • Kruppel-Like Transcription Factors / genetics
  • Leukocytes, Mononuclear / cytology*
  • Octamer Transcription Factor-3 / genetics
  • Proto-Oncogene Proteins c-myc / genetics
  • SOXB1 Transcription Factors / genetics

Substances

  • KLF4 protein, human
  • Kruppel-Like Factor 4
  • Kruppel-Like Transcription Factors
  • Octamer Transcription Factor-3
  • Proto-Oncogene Proteins c-myc
  • SOXB1 Transcription Factors