Abstract
We report the design and development of redox-responsive chain-shattering polymeric therapeutics (CSPTs). CSPTs were synthesized by condensation polymerization and further modified with poly(ethylene glycol) (PEG) via "Click" reaction. Size-controlled CSPT nanoparticles (NPs) were formed through nanoprecipitation with high drug loading (up to 18%); the particle size increased in a concentration dependent manner. Drug release from particles was well controlled over 48 h upon redox triggering. The anticancer efficacy of the CSPT NPs was validated both in vitro and in vivo.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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Animals
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Cell Survival / drug effects*
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Chemistry, Pharmaceutical
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Doxorubicin / chemistry
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Doxorubicin / toxicity*
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Drug Carriers
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Drug Delivery Systems
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Drug Liberation
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Humans
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MCF-7 Cells / chemistry
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MCF-7 Cells / drug effects*
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Mice
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Nanoparticles / chemistry*
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Oxidation-Reduction
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Paclitaxel / chemistry
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Paclitaxel / therapeutic use*
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Particle Size
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Polyethylene Glycols / chemistry*
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Polymerization
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Polymers / chemical synthesis*
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Polymers / chemistry
Substances
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Drug Carriers
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Polymers
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Polyethylene Glycols
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Doxorubicin
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Paclitaxel