Immune Response in Hepatitis B Virus Infection

Anthony Tan; Sarene Koh; Antonio Bertoletti

doi:10.1101/cshperspect.a021428

Immune Response in Hepatitis B Virus Infection

Cold Spring Harb Perspect Med. 2015 Jul 1;5(8):a021428. doi: 10.1101/cshperspect.a021428.

Authors

Anthony Tan¹, Sarene Koh², Antonio Bertoletti³

Affiliations

¹ Program Emerging Infectious Diseases, Duke-NUS Graduate Medical School, Singapore 169857.
² Viral Hepatitis Laboratory, Singapore Institute for Clinical Sciences, A*STAR, Singapore 117609.
³ Program Emerging Infectious Diseases, Duke-NUS Graduate Medical School, Singapore 169857 Viral Hepatitis Laboratory, Singapore Institute for Clinical Sciences, A*STAR, Singapore 117609 School of Immunity and Infection, College of Medical and Dental Science, University of Birmingham, Edgbaston, Birmingham B16 2TT, United Kingdom.

Abstract

Hepatitis B virus (HBV) can replicate within hepatocytes without causing direct cell damage. The host immune response is, therefore, not only essential to control the spread of virus infection, but it is also responsible for the inflammatory events causing liver pathologies. In this review, we discuss how HBV deals with host immunity and how we can harness it to achieve virus control and suppress liver damage.

Publication types

Review

MeSH terms

Adaptive Immunity / physiology
Female
Hepatitis B / immunology*
Hepatitis B / virology
Hepatitis B virus / immunology*
Hepatitis B, Chronic / immunology
Hepatitis B, Chronic / virology
Humans
Immunity, Cellular / immunology*
Immunity, Innate / immunology*
Male
Sensitivity and Specificity
Severity of Illness Index