Developing a Successful HIV Vaccine

J Infect Dis. 2015 Jul 15;212 Suppl 1(Suppl 1):S40-1. doi: 10.1093/infdis/jiv069.

Abstract

Human immunodeficiency virus (HIV) genome integration indicates that persistent sterilizing immunity will be needed for a successful vaccine candidate. This suggests a need for broad antibodies targeting the Env protein. Immunogens targeting gp120 have been developed that block infection in monkeys and mimic the modest success of the RV144 clinical trial in that protection is short-lived following a decline in antibody-depending cell-mediated cytotoxicity-like antibodies. Attempts to induce antibody persistence have been complicated by a loss of efficacy, presumably by increasing the number of HIV-target cells. The key seems to be achieving an immune balance.

Keywords: AIDS; HIV; T cells; antibodies; vaccine.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • AIDS Vaccines*
  • CD4-Positive T-Lymphocytes / immunology
  • CD4-Positive T-Lymphocytes / virology
  • Genome, Viral
  • HIV Antibodies
  • HIV Infections* / immunology
  • HIV Infections* / virology
  • HIV* / genetics
  • HIV* / immunology
  • HIV* / pathogenicity
  • Host-Pathogen Interactions
  • Humans
  • env Gene Products, Human Immunodeficiency Virus

Substances

  • AIDS Vaccines
  • HIV Antibodies
  • env Gene Products, Human Immunodeficiency Virus