Low grade serious carcinoma of the peritoneum in a BRCA1 carrier previously diagnosed with a "low-grade serous tubal intra-epithelial carcinoma" (STIC) on risk reducing surgery

Wen Yee Chay; Hugo M Horlings; Anna V Tinker; Karen A Gelmon; C Blake Gilks

doi:10.1016/j.gore.2015.03.007

Low grade serious carcinoma of the peritoneum in a BRCA1 carrier previously diagnosed with a "low-grade serous tubal intra-epithelial carcinoma" (STIC) on risk reducing surgery

Gynecol Oncol Rep. 2015 Mar 28:12:72-4. doi: 10.1016/j.gore.2015.03.007. eCollection 2015 Apr.

Authors

Wen Yee Chay¹, Hugo M Horlings², Anna V Tinker¹, Karen A Gelmon¹, C Blake Gilks³

Affiliations

¹ Department of Medical Oncology, BC Cancer Agency, Canada.
² Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia, Canada.
³ Vancouver General Hospital, BC, Canada ; University of British Columbia, Pathology and Laboratory Medicine, Canada.

Abstract

•Conventional definitions of STIC do not capture all lesions associated with serous neoplasia and the presence of abnormal p53 expression may be helpful diagnostically.•The management of STICs and tubal atypias remain uncertain.•The POINT Project is a registry set up to address this critical gap in knowledge.

Keywords: BRCA; Prophylactic salpingo-oophorectomy; Serous carcinoma; Serous tubal intraepithelial carcinoma; Tubal atypia.

Publication types

Case Reports