Improved survival of patients with hypermutation in uterine serous carcinoma

Alessandro D Santin; Stefania Bellone; Floriana Centritto; Joseph Schlessinger; Richard Lifton

doi:10.1016/j.gore.2015.01.005

Improved survival of patients with hypermutation in uterine serous carcinoma

Gynecol Oncol Rep. 2015 Jan 24:12:3-4. doi: 10.1016/j.gore.2015.01.005. eCollection 2015 Apr.

Authors

Alessandro D Santin, Stefania Bellone, Floriana Centritto, Joseph Schlessinger, Richard Lifton

Abstract

•Uterine serous carcinoma (USC) is an aggressive subtype of endometrial cancer.•Mutations in DNA polymerase ε gene (POLE) are detected in a subset of USC and confer a strong mutator phenotype.•USC patients diagnosed with POLE mutations experience a significantly better prognosis.

Keywords: Endometrial cancer; Polymerase epsilon somatic mutations; Uterine serous carcinoma.

Abstract

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