Platelet-Rich Plasma and Deproteinized Bovine Bone Matrix in Maxillary Sinus Lift Surgery: A Split-Mouth Histomorphometric Evaluation

Implant Dent. 2015 Oct;24(5):592-7. doi: 10.1097/ID.0000000000000293.

Abstract

Purpose: The purpose of this split-mouth controlled study was to evaluate and compare the amount of vital bone after lateral sinus lift surgery using either a mixture of pure platelet concentrate and deproteinized bovine bone mineral (test group) or solely deproteinized bovine bone as grafting material (control group).

Materials and methods: Six patients with edentulous posterior maxilla and a residual ridge height of less than 4 mm were recruited in this study. Six months after grafting procedure, 2 bone biopsies per patient were taken bilaterally from the anterolateral sinus wall. Histological and histomorphometrical analysis was carried out.

Results: A total of 10 sinus surgeries in 5 patients were analyzed. The mean percentage of vital bone was 22.72% ± 9.21% (range, 11.45%-33.30%) in the control group and 30.70% ± 7.89% (range, 18.30%-39.99%) in the test group.

Conclusion: The adjunct of pure platelet-rich plasma to deproteinized bovine bone mineral may enhance vital bone formation in the first 6 months after sinus floor augmentation. However, no statistically significant difference was found between groups (P = 0.18).

Publication types

  • Clinical Trial

MeSH terms

  • Aged
  • Animals
  • Biopsy
  • Bone Matrix / metabolism*
  • Bone Substitutes / therapeutic use*
  • Bone Transplantation / methods*
  • Cattle
  • Cone-Beam Computed Tomography
  • Dental Implantation, Endosseous / methods
  • Female
  • Humans
  • Male
  • Middle Aged
  • Platelet-Rich Plasma / metabolism*
  • Sinus Floor Augmentation / methods*

Substances

  • Bone Substitutes