Unmistakable Morphology? Infantile Malignant Osteopetrosis Resembling Juvenile Myelomonocytic Leukemia in Infants

Anne Strauss; Ingrid Furlan; Sandra Steinmann; Bernd Buchholz; Bernhard Kremens; Claudia Rossig; Selim Corbacioglu; Revathi Rajagopal; Georgia Lahr; Ayami Yoshimi; Brigitte Strahm; Charlotte M Niemeyer; Ansgar Schulz

doi:10.1016/j.jpeds.2015.04.064

Unmistakable Morphology? Infantile Malignant Osteopetrosis Resembling Juvenile Myelomonocytic Leukemia in Infants

J Pediatr. 2015 Aug;167(2):486-8. doi: 10.1016/j.jpeds.2015.04.064. Epub 2015 May 15.

Authors

Affiliations

¹ Division of Pediatric Hematology and Oncology, Department of Pediatrics and Adolescent Medicine, University of Freiburg, Freiburg, Germany. Electronic address: anne.strauss@uniklinik-freiburg.de.
² Department of Pediatrics and Adolescent Medicine, University Medical Center Ulm, Ulm, Germany.
³ Department of Pediatrics, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
⁴ Department of Pediatric Hematology and Oncology, University of Duisburg-Essen, Essen, Germany.
⁵ Department of Pediatric Hematology and Oncology, University Children's Hospital Muenster, Muenster, Germany.
⁶ Department of Pediatric Hematology, Oncology and Stem Cell Transplantation, University of Regensburg, Children's Hospital Regensburg, Regensburg, Germany.
⁷ Pediatric Hematology-Oncology Unit, University of Malaya Medical Center, Kuala Lumpur, Malaysia.
⁸ Division of Pediatric Hematology and Oncology, Department of Pediatrics and Adolescent Medicine, University of Freiburg, Freiburg, Germany.

PMID: 25982139
DOI: 10.1016/j.jpeds.2015.04.064

Abstract

The initial clinical and hematologic presentation of infantile malignant osteopetrosis may be indistinguishable from that of juvenile myelomonocytic leukemia in infants. Timely radiographic imaging, however, allows straightforward delineation of these 2 severe diseases and facilitates immediate initiation of appropriate therapy.

MeSH terms

Diagnosis, Differential
Female
Humans
Infant
Infant, Newborn
Leukemia, Myelomonocytic, Juvenile / diagnosis*
Male
Osteopetrosis / diagnosis*
Osteopetrosis / etiology
Osteopetrosis / therapy