Response to Brosch et al

Jussi Pihlajamäki; Carles Lerin; Dorota Kaminska; Sari Venesmaa; Paula Itkonen; Tanner Boes; Thomas Floss; Joshua Schroeder; Farrell Dearie; Sarah Crunkhorn; Furkan Burak; Josep C Jimenez-Chillaron; Tiina Kuulasmaa; Pekka Miettinen; Peter J Park; Imad Nasser; Zhenwen Zhao; Zhaiyi Zhang; Yan Xu; Wolfgang Wurst; Hongmei Ren; Andrew J Morris; Stefan Stamm; Allison B Goldfine; Markku Laakso; Mary Elizabeth Patti

doi:10.1016/j.cmet.2012.02.005

Response to Brosch et al

Cell Metab. 2012 Mar 7;15(3):267-269. doi: 10.1016/j.cmet.2012.02.005.

Authors

Jussi Pihlajamäki¹, Carles Lerin², Dorota Kaminska³, Sari Venesmaa⁴, Paula Itkonen⁴, Tanner Boes⁵, Thomas Floss⁶, Joshua Schroeder⁵, Farrell Dearie⁵, Sarah Crunkhorn⁵, Furkan Burak⁵, Josep C Jimenez-Chillaron⁵, Tiina Kuulasmaa⁴, Pekka Miettinen⁷, Peter J Park⁸, Imad Nasser⁹, Zhenwen Zhao¹⁰, Zhaiyi Zhang¹¹, Yan Xu¹⁰, Wolfgang Wurst¹², Hongmei Ren¹¹, Andrew J Morris¹¹, Stefan Stamm¹¹, Allison B Goldfine⁵, Markku Laakso⁴, Mary Elizabeth Patti⁵

Affiliations

¹ Research Division, Joslin Diabetes Center, Harvard Medical School, Boston, MA 02215, USA ; Department of Medicine, University of Eastern Finland, Kuopio 70211, Finland ; Department of Clinical Nutrition, University of Eastern Finland, Kuopio 70211, Finland.
² Research Division, Joslin Diabetes Center, Harvard Medical School, Boston, MA 02215, USA ; Diabetes and Obesity Laboratory, IDIBAPS-CIBERDEM, 08036 Barcelona, Spain.
³ Department of Clinical Nutrition, University of Eastern Finland, Kuopio 70211, Finland.
⁴ Department of Medicine, University of Eastern Finland, Kuopio 70211, Finland.
⁵ Research Division, Joslin Diabetes Center, Harvard Medical School, Boston, MA 02215, USA.
⁶ Helmholtz Zentrum München, Technische Universität München, Institut für Entwicklungsgenetik, Ingolstädter Landstrasse 1, 85764 Munich, Neuherberg, Germany.
⁷ Department of Surgery, University of Eastern Finland, Kuopio 70211, Finland.
⁸ Children's Hospital, Harvard Medical School, Boston, MA 02215, USA.
⁹ Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.
¹⁰ Department of Obstetrics and Gynecology, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
¹¹ Department of Molecular and Cellular Biochemistry, University of Kentucky, Lexington, KY 40536, USA.
¹² Helmholtz Zentrum München, Technische Universität München, Institut für Entwicklungsgenetik, Ingolstädter Landstrasse 1, 85764 Munich, Neuherberg, Germany ; MPI für Psychiatrie, Kraepelinstrasse 2-10, 80804 München, and Technical University Weihenstephan, Lehrstuhl für Entwicklungsgenetik, c/o Helmholtz Zentrum München, and DZNE-site Munich, c/o Adolf Butenandt Institute, LMU, Schillerstrasse 44, 80336 Munich, Germany.

Abstract

We would like to respond to Brosch et al. regarding our manuscript "Expression of the Splicing Factor Gene SFRS10 Is Reduced in Human Obesity and Contributes to Enhanced Lipogenesis" (Pihlajamäki et al., 2011b). Brosch performed RT-PCR in liver samples from 13 lean and 34 obese individuals, finding no differences in SFRS10 or LPIN1 expression. We wish to address points raised by Brosch, including experimental strategy and analysis of human SFRS10 expression.

Abstract

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