Infection, systemic inflammation, and Alzheimer's disease

Siok Lam Lim; Carlos J Rodriguez-Ortiz; Masashi Kitazawa

doi:10.1016/j.micinf.2015.04.004

Infection, systemic inflammation, and Alzheimer's disease

Microbes Infect. 2015 Aug;17(8):549-56. doi: 10.1016/j.micinf.2015.04.004. Epub 2015 Apr 22.

Authors

Siok Lam Lim¹, Carlos J Rodriguez-Ortiz¹, Masashi Kitazawa²

Affiliations

¹ Department of Molecular and Cell Biology, School of Natural Sciences, University of California, Merced, 5200 North Lake Road, Merced, CA 95343, USA.
² Department of Molecular and Cell Biology, School of Natural Sciences, University of California, Merced, 5200 North Lake Road, Merced, CA 95343, USA. Electronic address: mkitazawa@ucmerced.edu.

PMID: 25912134
DOI: 10.1016/j.micinf.2015.04.004

Abstract

Alzheimer's disease (AD) is a leading cause of dementia among elderly. Yet, its etiology remains largely unclear. In this review, we summarize studies that associate systemic infection and neuroinflammation with AD, while highlighting that early-life or life-long exposure to infectious agents predisposes one to develop AD at a later age.

Keywords: Alzheimer's disease; Environment; Infection; Inflammation; Risk factors; Sporadic.

Publication types

Review

MeSH terms

Alzheimer Disease / complications
Alzheimer Disease / etiology*
Humans
Infections / complications
Infections / pathology
Inflammation / complications
Inflammation / pathology
Risk Factors