Calnexin bridges the gap toward a pan-fungal vaccine

Cell Host Microbe. 2015 Apr 8;17(4):421-3. doi: 10.1016/j.chom.2015.03.012.

Abstract

Vaccines are needed to combat the global rise in fungal diseases. In this issue of Cell Host & Microbe, Wüthrich et al. (2015) identify calnexin as a target of antigen-specific CD4 T cell responses against multiple fungal pathogens. This study illustrates that a conserved epitope triggers convergent cell-mediated immune responses to confer heterologous antifungal immunity.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Comment

MeSH terms

  • Animals
  • Antigens, Fungal / immunology*
  • Ascomycota / immunology*
  • CD4-Positive T-Lymphocytes / drug effects*
  • CD4-Positive T-Lymphocytes / immunology*
  • Calnexin / immunology*
  • Cell Proliferation / drug effects*
  • Epitopes / immunology*

Substances

  • Antigens, Fungal
  • Epitopes
  • Calnexin