Differentiation of salivary bacterial profiles of subjects with periodontitis and dental caries

Daniel Belstrøm; Nils-Erik Fiehn; Claus H Nielsen; Vanja Klepac-Ceraj; Bruce J Paster; Svante Twetman; Palle Holmstrup

doi:10.3402/jom.v7.27429

Differentiation of salivary bacterial profiles of subjects with periodontitis and dental caries

J Oral Microbiol. 2015 Apr 7:7:27429. doi: 10.3402/jom.v7.27429. eCollection 2015.

Authors

Daniel Belstrøm¹, Nils-Erik Fiehn², Claus H Nielsen^{3

4}, Vanja Klepac-Ceraj⁵, Bruce J Paster^{6

7}, Svante Twetman⁸, Palle Holmstrup³

Affiliations

¹ Section of Periodontology, Microbiology, and Community Dentistry, School of Dentistry, Faculty of Health Science, University of Copenhagen, Copenhagen, Denmark; dbel@sund.ku.dk.
² Department of International Health, Immunology, and Microbiology, University of Copenhagen, Copenhagen, Denmark.
³ Section of Periodontology, Microbiology, and Community Dentistry, School of Dentistry, Faculty of Health Science, University of Copenhagen, Copenhagen, Denmark.
⁴ Institute for Inflammation Research, Department of Infectious Diseases and Rheumatology, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark.
⁵ Department of Biological Sciences, Wellesley College, Wellesley, MA, USA.
⁶ The Forsyth Institute, Department of Microbiology, Cambridge, MA, USA.
⁷ Department of Oral Medicine, Infection, and Immunity, Harvard School of Dental Medicine, Boston, MA, USA.
⁸ Section of Cariology, School of Dentistry, Faculty of Health Sciences, University of Copenhagen, Denmark.

Abstract

Bacterial profiles of saliva in subjects with periodontitis and dental caries have been demonstrated to differ from that of oral health. The aim of this comparative analysis of existing data generated by the Human Oral Microbe Identification Microarray (HOMIM) from 293 stimulated saliva samples was to compare bacterial profiles of saliva in subjects with periodontitis and dental caries.

Keywords: HOMIM; bacteria; dental caries; periodontitis; saliva.