Influence of the intramedullary nail preparation method on nail's mechanical properties and degradation rate

Mater Sci Eng C Mater Biol Appl. 2015 Jun:51:99-106. doi: 10.1016/j.msec.2015.02.043. Epub 2015 Feb 25.

Abstract

When it comes to the treatment of long bone fractures, scientists are still investigating new materials for intramedullary nails and different manufacturing methods. Some of the most promising materials used in the field are resorbable polymers and their composites, especially since there is a wide range of potential manufacturing and processing methods. The aim of this work was to select the best manufacturing method and technological parameters to obtain multiphase, and multifunctional, biodegradable intramedullary nails. All composites were based on a poly(l-lactide) matrix. Either magnesium alloy wires or carbon and alginate fibres were introduced in order to reinforce the nails. The polylactide matrix was also modified with tricalcium phosphate and gentamicin sulfate. The composite nails were manufactured using three different methods: forming from solution, injection moulding and hot pressing. The effect of each method of manufacturing on mechanical properties and degradation rate of the nails was evaluated. The study showed that injection moulding provides higher uniformity and homogeneity of the particle-modified polylactide matrix, whereas hot pressing favours applying higher volume fractions of fibres and their better impregnation with the polymer matrix. Thus, it was concluded that the fabrication method should be individually selected dependently on the nail's desired phase composition.

Keywords: Biodegradable composites; Forming from solution; Hot pressing; Injection moulding; Intramedullary nails.

Publication types

  • Comparative Study
  • Evaluation Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alginates / chemistry*
  • Biocompatible Materials / chemistry*
  • Bone Nails*
  • Carbon / chemistry*
  • Carbon Fiber
  • Elastic Modulus
  • Equipment Failure Analysis
  • Fracture Fixation, Intramedullary / instrumentation*
  • Glucuronic Acid / chemistry
  • Hardness
  • Heating / methods
  • Hexuronic Acids / chemistry
  • Magnesium / chemistry*
  • Prosthesis Design
  • Tensile Strength

Substances

  • Alginates
  • Biocompatible Materials
  • Carbon Fiber
  • Hexuronic Acids
  • Carbon
  • Glucuronic Acid
  • Magnesium