Preferential carriage of class 2 integrons in Acinetobacter baumannii CC113 and novel singletons

Epidemiol Infect. 2015 Oct;143(14):3118-21. doi: 10.1017/S0950268815000060. Epub 2015 Feb 20.

Abstract

Our understanding of the distribution of integrons associated with multidrug resistance in Acinetobacter baumannii isolates around the world remains incomplete. The association between the class 1 and 2 integron A. baumannii-positive isolates (n = 60), recovered since 1982 from 11 Argentinean hospitals, and the circulating lineages, was investigated. While class 2 integrons were highly significantly associated with clonal lineage CC113B/CC79P (P = 0·009) and novel singletons (P = 0·001), class 1 integrons were found not to be associated with CC109B/CC1P or other lineages. The study reveals a differential distribution of class 2 integrons in lineages, and suggests that the prevalence of intI2 in Argentina is related to the emergence of novel singletons in recent years and to the abundance of CC113B/CC79P, which has been the local dominant lineage for several decades.

Keywords: Acinetobacter; integron; lineages.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acinetobacter Infections / epidemiology
  • Acinetobacter Infections / microbiology*
  • Acinetobacter baumannii / classification*
  • Acinetobacter baumannii / genetics*
  • Acinetobacter baumannii / isolation & purification
  • Argentina / epidemiology
  • Drug Resistance, Multiple, Bacterial
  • Genotype
  • Humans
  • Integrons*
  • Molecular Epidemiology