The importance of cooperation: partnerless NFAT induces T cell exhaustion

Bertram Bengsch; E John Wherry

doi:10.1016/j.immuni.2015.01.023

The importance of cooperation: partnerless NFAT induces T cell exhaustion

Immunity. 2015 Feb 17;42(2):203-205. doi: 10.1016/j.immuni.2015.01.023.

Authors

Bertram Bengsch¹, E John Wherry²

Affiliations

¹ Institute for Immunology, Department of Microbiology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA.
² Institute for Immunology, Department of Microbiology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA. Electronic address: wherry@mail.med.upenn.edu.

PMID: 25692694
DOI: 10.1016/j.immuni.2015.01.023

Abstract

Downstream of costimulatory pathways, complexes of transcription factors NFAT and AP-1 promote effector T cell differentiation. In this issue of Immunity, Martinez et al. report that monomeric NFAT binding in the absence of a transcriptional partner induces a gene expression program involved in T cell exhaustion.

Publication types

Comment

MeSH terms

Animals
CD8-Positive T-Lymphocytes / immunology*
Clonal Anergy / genetics*
NFATC Transcription Factors / physiology*
Recombinant Proteins / pharmacology*
Transcription Factor AP-1 / metabolism*

Substances

NFATC Transcription Factors
Nfatc2 protein, mouse
Recombinant Proteins
Transcription Factor AP-1