Ezh2 lines up the chromatin in T regulatory cells

Chuan Wu; Zuojia Chen; Vijay K Kuchroo

doi:10.1016/j.immuni.2015.01.019

Ezh2 lines up the chromatin in T regulatory cells

Immunity. 2015 Feb 17;42(2):201-203. doi: 10.1016/j.immuni.2015.01.019.

Authors

Chuan Wu¹, Zuojia Chen¹, Vijay K Kuchroo²

Affiliations

¹ Evergrande Center for Immunologic Diseases, Harvard Medical School, Brigham and Women's Hospital, Boston, MA 02115, USA.
² Evergrande Center for Immunologic Diseases, Harvard Medical School, Brigham and Women's Hospital, Boston, MA 02115, USA. Electronic address: vkuchroo@evergrande.hms.harvard.edu.

Abstract

Epigenetic modulation is critical for regulating the development and function of T cells. In this issue of Immunity, DuPage et al. (2015) show that the chromatin-modifying enzyme Ezh2 induced by CD28 costimulation is essential for regulatory T (Treg) cell maintenance during activation and differentiation.

Publication types

Comment

MeSH terms

Animals
CD28 Antigens / immunology*
Enhancer of Zeste Homolog 2 Protein
Female
Lymphocyte Activation / immunology*
Polycomb Repressive Complex 2 / immunology*
T-Lymphocytes, Regulatory / immunology*

Substances

CD28 Antigens
Enhancer of Zeste Homolog 2 Protein
Ezh2 protein, mouse
Polycomb Repressive Complex 2

Grants and funding

K99 AI110649/AI/NIAID NIH HHS/United States