Canine multi-drug resistance-1 mutation prevalence: A South African perspective

J S Afr Vet Assoc. 2014 Nov 14;85(1):1139. doi: 10.4102/jsava.v85i1.1139.

Abstract

The multi-drug resistance (mdr-1) gene mutation is a phenomenon well known to current veterinary practitioners. The mutation causes a predisposition for, amongst other phenomena, macrocyclic lactone-induced neurotoxicosis in affected canines, a condition that can be fatal. Various herding dog breeds can be heterozygous or homozygous for the mutation, and prevalence differs only slightly in dog populations between geographical regions. This report provides prevalence data of the canine mdr-1 mutation in 306 South African dogs.

MeSH terms

  • ATP Binding Cassette Transporter, Subfamily B, Member 1 / genetics
  • ATP Binding Cassette Transporter, Subfamily B, Member 1 / metabolism*
  • Animals
  • Dog Diseases / chemically induced*
  • Dog Diseases / epidemiology
  • Dog Diseases / genetics
  • Dogs
  • Genetic Testing / veterinary*
  • Mutation
  • Neurotoxicity Syndromes / epidemiology
  • Neurotoxicity Syndromes / genetics
  • Neurotoxicity Syndromes / veterinary*
  • South Africa / epidemiology

Substances

  • ATP Binding Cassette Transporter, Subfamily B, Member 1