Cutaneous bacillary angiomatosis due to Bartonella quintana in a renal transplant recipient

Transpl Int. 2015 May;28(5):626-31. doi: 10.1111/tri.12539. Epub 2015 Feb 18.

Abstract

Bacillary angiomatosis (BA) is a disorder of neovascular proliferation involving skin and other organs of immunosuppressed patients caused by Bartonella species. BA has been recognized in both immunocompetent and immunodeficient patients, mostly in human immunodeficiency virus (HIV)-infected persons, much more rare in those with other immunodeficiencies, including organ transplantation. Diagnosis is based on serologic analysis, culture and molecular biology [detection of Bartonella species deoxyribonucleic acid (DNA) in tissue biopsy extracts by real-time polymerase chain reaction (PCR)]. All immunosuppressed patients with BA should be treated with antibiotics because of potentially life-threatening course of the disease. We report the first case of cutaneous bacillary angiomatosis due to Bartonella quintana in renal transplant recipient. This presentation demonstrates that BA should be considered a differential diagnosis in immunocompromised patients presenting with fever and cutaneous angioma-like lesions.

Keywords: Bartonella quintana; bacillary angiomatosis; immunosuppression; renal transplantation.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Angiomatosis, Bacillary / immunology*
  • Angiomatosis, Bacillary / microbiology
  • Anti-Bacterial Agents / therapeutic use
  • Bartonella quintana*
  • Biopsy
  • Child
  • DNA / chemistry
  • Female
  • Humans
  • Immunosuppression Therapy
  • Immunosuppressive Agents / chemistry
  • Kidney Failure, Chronic / complications
  • Kidney Failure, Chronic / surgery
  • Kidney Transplantation / adverse effects*
  • Male
  • Middle Aged
  • Postoperative Complications
  • Real-Time Polymerase Chain Reaction
  • Young Adult

Substances

  • Anti-Bacterial Agents
  • Immunosuppressive Agents
  • DNA