SERS encoded silver pyramids for attomolar detection of multiplexed disease biomarkers

Adv Mater. 2015 Mar 11;27(10):1706-11. doi: 10.1002/adma.201402244. Epub 2015 Jan 14.

Abstract

Three disease biomarkers can simultaneously be detected at the attomolar level because of a novel surface-enhanced Raman scattering (SERS) encoded silver pyramid sensing system. This newly designed pyramidal sensor with well-controlled geometry exhibits highly sensitive, selective, and reproducible SERS signals, and holds promising potential for biodetection applications.

Keywords: biomarkers; detectors; nanoparticles; self-assembly; silver particles.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aniline Compounds / chemistry
  • Biomarkers / analysis*
  • DNA / chemistry
  • Electromagnetic Phenomena
  • Humans
  • Microscopy, Electron, Transmission
  • Mucin-1 / analysis
  • Prostate-Specific Antigen / analysis
  • Scattering, Small Angle
  • Serum Albumin / analysis
  • Silver Compounds* / chemistry
  • Solutions
  • Spectrum Analysis, Raman / instrumentation
  • Spectrum Analysis, Raman / methods*
  • Sulfhydryl Compounds / chemistry
  • Thrombin / analysis
  • Tomography

Substances

  • Aniline Compounds
  • Biomarkers
  • Mucin-1
  • Serum Albumin
  • Silver Compounds
  • Solutions
  • Sulfhydryl Compounds
  • 4-aminothiophenol
  • DNA
  • Thrombin
  • Prostate-Specific Antigen