ZMP: a master regulator of one-carbon metabolism

Mol Cell. 2015 Jan 22;57(2):203-4. doi: 10.1016/j.molcel.2015.01.012.

Abstract

In this issue, Kim et al. (2015) show that ZMP (5-aminoimidazole-4-carboxamide ribonucleotide) binds to and activates a conserved riboswitch to regulate expression of one-carbon metabolism genes.

Publication types

  • Comment

MeSH terms

  • Animals
  • Endosomes / enzymology*
  • Humans
  • Male
  • Mechanistic Target of Rapamycin Complex 1
  • Multiprotein Complexes / physiology*
  • Phagosomes / enzymology*
  • Protein Processing, Post-Translational*
  • TOR Serine-Threonine Kinases / physiology*
  • Tumor Suppressor Proteins / metabolism*

Substances

  • Multiprotein Complexes
  • Tumor Suppressor Proteins
  • UVRAG protein, human
  • Mechanistic Target of Rapamycin Complex 1
  • TOR Serine-Threonine Kinases