Clinical pharmacology of analgesic drugs in cattle

Matthew L Stock; Johann F Coetzee

doi:10.1016/j.cvfa.2014.11.002

Clinical pharmacology of analgesic drugs in cattle

Vet Clin North Am Food Anim Pract. 2015 Mar;31(1):113-38, vi-vii. doi: 10.1016/j.cvfa.2014.11.002. Epub 2015 Jan 8.

Authors

Matthew L Stock¹, Johann F Coetzee²

Affiliations

¹ Department of Veterinary Diagnostic and Production Animal Medicine, College of Veterinary Medicine, Iowa State University, 2448 Lloyd Vet Med, Ames, IA 50011, USA.
² Department of Veterinary Diagnostic and Production Animal Medicine, College of Veterinary Medicine, Iowa State University, 2448 Lloyd Vet Med, Ames, IA 50011, USA. Electronic address: hcoetzee@iastate.edu.

PMID: 25578387
DOI: 10.1016/j.cvfa.2014.11.002

Abstract

Providing pain relief in cattle is challenging. In the absence of labeled drugs, the Animal Medicinal Drug Use Clarification Act regulates the extralabel drug use of analgesics in cattle within the United States. Given the variety of pharmacokinetic and pharmacodynamic properties of pain-relieving drugs, evidence needs to drive the development of analgesic protocols for cattle during pain-related events. This article reviews the commonly used analgesics investigated in cattle including local anesthetics, nonsteroidal anti-inflammatory drugs, opioids, α2-agonists, N-methyl-d-aspartate receptor antagonists, and gabapentin. These compounds are examined with respect to evidence of analgesia in cattle during pain states.

Keywords: Gabapentin; Local anesthetics; N-methyl-d-aspartate receptor antagonists; Nonsteroidal anti-inflammatory drugs; Opioids; α2-Agonists.

Publication types

Research Support, U.S. Gov't, Non-P.H.S.
Review

MeSH terms

Analgesics / pharmacokinetics
Analgesics / therapeutic use*
Animals
Cattle
Cattle Diseases / drug therapy*
Cattle Diseases / metabolism
Female
Pain Management / methods
Pain Management / veterinary*
Randomized Controlled Trials as Topic / veterinary

Substances

Analgesics