Flavonoids and arylbenzofurans from the rhizomes and roots of Sophora tonkinensis with IL-6 production inhibitory activity

Bioorg Med Chem Lett. 2014 Dec 15;24(24):5644-5647. doi: 10.1016/j.bmcl.2014.10.077. Epub 2014 Oct 30.

Abstract

Three new compounds (1-3) and 20 known compounds were isolated from the rhizomes and roots of Sophora tonkinensis, and all the isolates were tested for their inhibitory activity against IL-6 production in HMC-1 cells stimulated by PMA plus ionophore, A23187. Of the tested compounds, compounds 1, 5, 9, and 21 were found to potently inhibit IL-6 production with IC50 values of 1.62, 0.73, 3.01, and 4.02 μM, respectively.

Keywords: Anti-allergy; Arylbenzofruran; Flavonoid; Interleukin-6; Sophora tonkinensis.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Benzofurans / chemistry*
  • Benzofurans / isolation & purification
  • Calcimycin / pharmacology
  • Cell Line
  • Flavanones / chemistry*
  • Flavanones / isolation & purification
  • Flavanones / pharmacology
  • Flavonoids / chemistry*
  • Flavonoids / isolation & purification
  • Humans
  • Interleukin-6 / metabolism*
  • Magnetic Resonance Spectroscopy
  • Mast Cells / cytology
  • Mast Cells / drug effects
  • Mast Cells / metabolism
  • Molecular Conformation
  • Plant Extracts / chemistry
  • Plant Roots / chemistry
  • Plant Roots / metabolism
  • Rhizome / chemistry
  • Rhizome / metabolism
  • Sophora / chemistry*
  • Sophora / metabolism
  • Terpenes / chemistry*
  • Terpenes / isolation & purification
  • Terpenes / pharmacology
  • Tetradecanoylphorbol Acetate / pharmacology

Substances

  • 2'-hydroxyglabrol
  • 3-methylmaackiapterocarpan B
  • Benzofurans
  • Flavanones
  • Flavonoids
  • Interleukin-6
  • Plant Extracts
  • Terpenes
  • Calcimycin
  • benzofuran
  • Tetradecanoylphorbol Acetate