Biomarkers and physiopathology in the cardiorenal syndrome

Antoine Bouquegneau; Jean-Marie Krzesinski; Pierre Delanaye; Etienne Cavalier

doi:10.1016/j.cca.2014.10.041

Biomarkers and physiopathology in the cardiorenal syndrome

Clin Chim Acta. 2015 Mar 30:443:100-7. doi: 10.1016/j.cca.2014.10.041. Epub 2014 Oct 31.

Authors

Antoine Bouquegneau¹, Jean-Marie Krzesinski², Pierre Delanaye², Etienne Cavalier³

Affiliations

¹ Department of Nephrology, Dialysis, Transplantation, University of Liège, CHU Sart Tilman, 4000 Liège, Belgium. Electronic address: antoine.bouquegneau@chu.ulg.ac.be.
² Department of Nephrology, Dialysis, Transplantation, University of Liège, CHU Sart Tilman, 4000 Liège, Belgium.
³ Department of Biochemistry, University of Liège, CHU Sart Tilman, 4000 Liège, Belgium.

PMID: 25444738
DOI: 10.1016/j.cca.2014.10.041

Abstract

Acute cardiorenal syndrome (CRS) corresponds to an association of acute heart failure and a worsening of renal function. The detection of acute kidney injury (AKI) unfortunately occurs at a late stage of CRS, leading to an increased mortality of the patients. In this review, we described the pathophysiology of CRS and discussed the potential interest of biochemical biomarkers (namely creatinine, cystatin C, NGAL, KIM-1, fatty acid binding protein, Nacetyl-β-D-glucosaminidase and IL-18) that could potentially help to detect AKI earlier and thus reduce the morbi-mortality of the patients suffering from CRS.

Keywords: Acute kidney injury; Cardiorenal syndrome; Creatinine; Cystatine; Kidney failure; NGAL.

Publication types

Review

MeSH terms

Acute Disease
Biomarkers / analysis
Cardio-Renal Syndrome / diagnosis
Cardio-Renal Syndrome / physiopathology*
Humans

Substances

Biomarkers