Serum concentration of high density lipoproteins (HDLs) in leishmaniotic dogs

Fabrizio Ibba; Gabriele Rossi; Sara Meazzi; Alessia Giordano; Saverio Paltrinieri

doi:10.1016/j.rvsc.2014.11.011

Serum concentration of high density lipoproteins (HDLs) in leishmaniotic dogs

Res Vet Sci. 2015 Feb:98:89-91. doi: 10.1016/j.rvsc.2014.11.011. Epub 2014 Nov 18.

Authors

Fabrizio Ibba¹, Gabriele Rossi², Sara Meazzi², Alessia Giordano³, Saverio Paltrinieri⁴

Affiliations

¹ Department of Veterinary Sciences and Public Health, University of Milan, Via Celoria 10, 20133, Milan, Italy; Veterinary Clinic Poggio di Pini, Capoterra (CA), Italy.
² Department of Veterinary Sciences and Public Health, University of Milan, Via Celoria 10, 20133, Milan, Italy.
³ Department of Veterinary Sciences and Public Health, University of Milan, Via Celoria 10, 20133, Milan, Italy; Clinical Pathology Laboratory, Veterinary Teaching Hospital, University of Milan, Via dell'Università 6, 26900, Lodi, Italy.
⁴ Department of Veterinary Sciences and Public Health, University of Milan, Via Celoria 10, 20133, Milan, Italy; Clinical Pathology Laboratory, Veterinary Teaching Hospital, University of Milan, Via dell'Università 6, 26900, Lodi, Italy. Electronic address: saverio.paltrinieri@unimi.it.

PMID: 25440996
DOI: 10.1016/j.rvsc.2014.11.011

Abstract

In order to assess whether the concentration of high density lipoproteins (HDLs) changes in leishmaniotic dogs before and after treatment, HDL cholesterol (HDL-Chol and HDL%), C reactive protein (CRP) and activity of the antioxidant enzyme paraoxonase (PON-1) were measured in sera from 10 controls and 10 leishmaniotic dogs. Seven of these latter were sampled also 3, 7, 14, 21 and 28 days after treatment with antimonials and allopurinol. HDL-chol, and PON-1 were low in leishmaniotic dogs at admission and increased after treatment. HDL-chol and HDL% correlated positively with PON-1 and negatively with CRP suggesting that HDLs decrease through an oxidative mechanism. Therefore, HDLs may be used to monitor the magnitude of oxidation associated with inflammation in leishmaniotic dogs.

Keywords: Canine leishmaniasis; Clinical pathology; Companion animal medicine; Inflammation; Parasitology.

MeSH terms

Animals
Antioxidants / therapeutic use*
Antiprotozoal Agents / therapeutic use*
Aryldialkylphosphatase / therapeutic use*
C-Reactive Protein / metabolism
Cholesterol, HDL / blood
Dog Diseases / blood*
Dog Diseases / drug therapy*
Dog Diseases / parasitology
Dogs
Female
Leishmaniasis / blood
Leishmaniasis / drug therapy
Leishmaniasis / parasitology
Leishmaniasis / veterinary*
Lipoproteins, HDL / blood*
Male
Oxidation-Reduction

Substances

Antioxidants
Antiprotozoal Agents
Cholesterol, HDL
Lipoproteins, HDL
C-Reactive Protein
Aryldialkylphosphatase