SWI/SNF proteins as targets in cancer therapy

Santiago Schiaffino-Ortega; Carlos Balinas; Marta Cuadros; Pedro P Medina

doi:10.1186/s13045-014-0081-5

SWI/SNF proteins as targets in cancer therapy

J Hematol Oncol. 2014 Nov 13:7:81. doi: 10.1186/s13045-014-0081-5.

Authors

Santiago Schiaffino-Ortega¹, Carlos Balinas², Marta Cuadros^{3

4}, Pedro P Medina^{5

6}

Affiliations

¹ GENyO, Centre for Genomics and Oncological Research: Pfizer / University of Granada / Andalusian Regional Government, Granada, Spain. santiago.schiaffino@genyo.es.
² GENyO, Centre for Genomics and Oncological Research: Pfizer / University of Granada / Andalusian Regional Government, Granada, Spain. Carlos.balinas@genyo.es.
³ Department of Biochemistry and Molecular Biology, University of Granada, Granada, Spain. marta.cuadros@genyo.es.
⁴ GENyO, Centre for Genomics and Oncological Research: Pfizer / University of Granada / Andalusian Regional Government, Granada, Spain. marta.cuadros@genyo.es.
⁵ Department of Biochemistry and Molecular Biology, University of Granada, Granada, Spain. pedromedina@ugr.es.
⁶ GENyO, Centre for Genomics and Oncological Research: Pfizer / University of Granada / Andalusian Regional Government, Granada, Spain. pedromedina@ugr.es.

Abstract

Recent identification of synthetic lethal interactions involving several proteins of the SWI/SNF complex discussed in this Research Highlight has opened the possibility of new cancer therapeutic approaches.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Chromosomal Proteins, Non-Histone / genetics
Chromosomal Proteins, Non-Histone / metabolism*
Humans
Molecular Targeted Therapy
Neoplasms / genetics
Neoplasms / metabolism*
Neoplasms / therapy*
Transcription Factors / genetics
Transcription Factors / metabolism*

Substances

Chromosomal Proteins, Non-Histone
Transcription Factors