Rapid childhood T-ALL growth in xenograft models correlates with mature phenotype and NF-κB pathway activation but not with poor prognosis

Leukemia. 2015 Apr;29(4):977-80. doi: 10.1038/leu.2014.317. Epub 2014 Nov 5.
No abstract available

Publication types

  • Letter
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Animals
  • Antineoplastic Agents / pharmacology*
  • Apoptosis / drug effects
  • Cell Cycle / drug effects
  • Child
  • Coculture Techniques
  • Gene Expression Regulation, Neoplastic*
  • Graft Survival
  • Humans
  • Mice
  • Mice, SCID
  • NF-kappa B / antagonists & inhibitors
  • NF-kappa B / genetics*
  • NF-kappa B / metabolism
  • Nitriles / pharmacology*
  • Oncogene Proteins, Fusion / genetics*
  • Oncogene Proteins, Fusion / metabolism
  • Phenotype
  • Precursor T-Cell Lymphoblastic Leukemia-Lymphoma / genetics*
  • Precursor T-Cell Lymphoblastic Leukemia-Lymphoma / metabolism
  • Precursor T-Cell Lymphoblastic Leukemia-Lymphoma / pathology
  • Prognosis
  • Signal Transduction
  • Stromal Cells / cytology
  • Stromal Cells / metabolism
  • Sulfones / pharmacology*
  • T-Lymphocytes / metabolism
  • T-Lymphocytes / pathology
  • Transplantation, Heterologous
  • Xenograft Model Antitumor Assays
  • Young Adult

Substances

  • 3-(4-methylphenylsulfonyl)-2-propenenitrile
  • Antineoplastic Agents
  • NF-kappa B
  • Nitriles
  • Oncogene Proteins, Fusion
  • SIL-TAL1 fusion protein, human
  • Sulfones