Coenzyme Q10 and immunity: A case report and new implications for treatment of recurrent infections in metabolic diseases

Clin Immunol. 2014 Dec;155(2):209-12. doi: 10.1016/j.clim.2014.09.010. Epub 2014 Sep 28.

Abstract

Coenzyme Q10 (CoQ10) deficiency can manifest diversely, from isolated myopathy to multisystem involvement. Immune dysregulation has not been reported as a feature of the disease. We report a four-year old girl with failure to thrive, recurrent infections, developmental delay with hypotonia, and CoQ10 deficiency with impaired immune function, which improved after CoQ10 and immunoglobulin replacement therapy. Immune dysfunction in CoQ10 deficiency should be considered and treated appropriately.

Keywords: Coenzyme Q(10;); Immune deficiency; Mitochondria;; Recurrent infections;.

Publication types

  • Case Reports

MeSH terms

  • Ataxia / diagnosis
  • Ataxia / drug therapy
  • Ataxia / immunology*
  • Ataxia / metabolism*
  • Child, Preschool
  • Enzyme Replacement Therapy
  • Female
  • Humans
  • Immunity / physiology*
  • Immunoglobulin G / blood
  • Immunoglobulin G / immunology
  • Lymphocyte Subsets / immunology
  • Lymphocyte Subsets / metabolism
  • Mitochondrial Diseases / diagnosis
  • Mitochondrial Diseases / drug therapy
  • Mitochondrial Diseases / immunology*
  • Mitochondrial Diseases / metabolism*
  • Muscle Weakness / diagnosis
  • Muscle Weakness / drug therapy
  • Muscle Weakness / immunology*
  • Muscle Weakness / metabolism*
  • Treatment Outcome
  • Ubiquinone / analogs & derivatives*
  • Ubiquinone / deficiency*
  • Ubiquinone / immunology
  • Ubiquinone / metabolism
  • Ubiquinone / therapeutic use

Substances

  • Immunoglobulin G
  • Ubiquinone
  • coenzyme Q10

Supplementary concepts

  • Coenzyme Q10 Deficiency